Compounds in development act on targets like fatty acid synthase and carnitine palmitoyl transferase FASgen is studying the effects of inhibition of the fatty acid biosynthesis pathway on the regulation of appetite and weight loss. The firm has developed various families of compounds that act on well-identified targets in the pathway, including fatty acid synthase FAS , carnitine palmitoyl transferase-1 CPT-1 , and mitochondrial glyceraol-3aclytransferase GPAT. The research is partly conducted in cooperation with labs at Johns Hopkins University. FASgen was founded in by four researchers from Johns Hopkins to create therapeutics based on the selective inhibition of fatty acid biosynthesis. The company has an exclusive license from Johns Hopkins to more than 15 years of research in the field. An additional group of compounds have shown potential in the treatment of tuberculosis TB including multiple drug-resistant TB and latent TB infections.
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We've updated our Privacy Policy to make it clearer how we use your personal data. We use cookies to provide you with a better experience, read our Cookie Policy. FASgen, Inc. FAS31 is an inhibitor of fatty acid synthase FASi , an enzyme that is highly expressed in many human cancers. Numerous studies have shown that pharmacological FAS inhibition is cytotoxic to a variety of human xenograft models without toxicity.
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Method of neuroprotection by pharmacological inhibition of AMP-activated protein kinase. Patent number: Abstract: A method of neuroprotection which comprises administration of an AMPK inhibitor to a patient who is experiencing or has experienced a stroke, the compound being an AMPK inhibitor. Treatments with these agents significantly reduce the size of infarcts, and therefore minimize the loss of brain tissue and neurons. Thus, function can be preserved after stroke or ischemic injury in the brain. Similarly, neuronal loss can be minimized in degenerative diseases that cause neuronal compromise by perturbing energy utilization and availability in neurons.
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